Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8208519 | Applied Radiation and Isotopes | 2018 | 6 Pages |
Abstract
In the process of developing [18F]FBEM coupled target peptide, we have instituted a robust automated synthesis of [18F]FBEM, a sulfhydryl (-SH) site specific agent for radiolabeling of peptides and proteins. The radiosynthesis generated 1.67-3.89 GBq (45.1-105.1â¯mCi, 7.5-18.8% non-decay corrected yield) of [18F]FBEM from 22.2 GBq (600â¯mCi) of starting [18F]fluoride with molar activity of 31.8â¯Â±â¯5.3 GBq/µmol (0.86â¯Â±â¯0.14â¯mCi/nmol) (nâ¯=â¯3) at the end of synthesis. Radiochemical purity was greater than 98%, and total synthesis time was ~90â¯min.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Keunpoong Lim, Jim Ropchan, Dale O. Kiesewetter, Xiaoyuan Chen, Yiyun Huang,