| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8208548 | Applied Radiation and Isotopes | 2018 | 23 Pages |
Abstract
Pharmaceutical grade DOTATOC kits compliant with all the quality control criteria were formulated and radiolabeled with 68Ga in high yields. Comparison with module-based 68Ga-DOTATOC established product equivalency. Clinical utility was evaluated in patients with histopathologically confirmed well-differentiated neuroendocrine tumors. Kit-based preparation of 68Ga-DOTATOC could identify sites of primary and metastatic disease. PET/CT images of patients conformed to the established criteria for somatostatin imaging agents and clinical expectations. Results of this study emphasize the potential of kit-based 68Ga-DOTATOC for PET imaging of neuroendocrine tumors.
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Authors
Usha Pandey, Aruna Korde, Archana Mukherjee, Ajit Shinto, K.K. Kamaleswaran, Raghi P. Jose, Naresh Gamre, Ashutosh Dash,