Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8208732 | Applied Radiation and Isotopes | 2018 | 16 Pages |
Abstract
Cerebral damage secondary to the vasospasm due to subarachnoid hemorrhage (SAH) is an important cause of morbid-mortality. We propose the use of the PET tracer [18F]Fluoromisonidazole to visualize the hypoxia due to the vasospasm. On the other hand [18F]Fluoromisonidazole synthesis process was optimized, avoiding HPLC purification using SPE cartridges instead, and reducing some synthesis steps. [18F]Fluoromisonidazole in vitro stability was tested for ten hours, and in vivo PET/CT images showed higher cerebral uptake in hemorrhagic animals than in control rats.
Related Topics
Physical Sciences and Engineering
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Radiation
Authors
Laura Fernandez-Maza, Juan Jose Egea-Guerrero, Marcin Balcerzyk, Gemma Civantos-Jubera, Elena Gordillo-Escobar, Angel Vilches-Arenas, Isabel Fernandez-Gomez, Angel Parrado-Gallego, Francisco Murillo-Cabezas,