Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8208767 | Applied Radiation and Isotopes | 2018 | 5 Pages |
Abstract
In the framework of an international BIPM comparison (Bureau International des Poids et Mesures), the activity standardization of 68Ge in a solution of 68Ge/68Ga in equilibrium provided by NIST was carried out at LNHB. This exercise was organized to meet the growing interest in 68Ga as a radiopharmaceutical in nuclear medicine services (e.g. as a surrogate of 18F for PET imaging). Due to the volatility of germanium, the activity standardization of 68Ge was investigated at LNHB by means of 4Ïβâγ coincidence counting based on Cherenkov measurements. This technique was applied to take advantage of the Cherenkov threshold (~ 260 keV in aqueous solutions) in order to prevent counting from electron-capture events associated with 68Ge disintegrations. Cherenkov counting was performed using glass and polyethylene vials and the resulting activity concentrations were compared with 4Ïβâγ coincidence measurements based on liquid scintillation. The efficiency-extrapolation curve obtained with Cherenkov measurements in glass vials was compared to Monte Carlo simulations based on the Geant4 code.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
C. Bobin, C. Thiam, J. Bouchard,