Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8208846 | Applied Radiation and Isotopes | 2018 | 26 Pages |
Abstract
Absorbed doses to human organs from 188Re-Rituximab in the free form and bound to superparamagnetic iron oxide nanoparticles were predicted from results of the radiopharmaceutical biodistribution studies in mice by the RADAR method. Overall, equivalent and effective doses to human organs from the radiopharmaceutical on the nanoparticles were higher because of the enhanced permeability and retention effect. Liver, spleen and kidneys received higher equivalent doses than other organs (5.29, 3.70 and 3.06Â mSv/MBq, respectively, for the free radiopharmaceutical and 6.12, 3.96 and 3.93Â mSv/MBq for the drug on the nanoparticles).
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Authors
Bakhtiar Azadbakht, Hossein Afarideh, Mohammad Ghannadi-Maragheh, Ali Bahrami-Samani, Hassan Yousefnia,