Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8208891 | Applied Radiation and Isotopes | 2017 | 8 Pages |
Abstract
This work characterizes the radiochemical synthesis, purification, and formulation of [18F]THK-5351, a tau PET radioligand, and develops an automated radiosynthesis routine (ELIXYS, Sofie Biosciences). Nucleophilic radiofluorination reaction was complete by 7 min at 110 °C with radiochemical yields proportional to precursor mass (0.1-0.5 mg). Optimized HPLC purification produced radiotracer product with no chemical impurities observed on analytical HPLC in formulation. Automated radiosynthesis (ELIXYS), HPLC purification and formulation was completed in 86 min producing formulated product suitable for human research use.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Tobey J. Betthauser, Paul A. Ellison, Dhanabalan Murali, Patrick J. Lao, Todd E. Barnhart, Shozo Furumoto, Nobuyuki Okamura, Sterling C. Johnson, Jonathan W. Engle, Robert J. Nickles, Bradley T. Christian,