| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8208962 | Applied Radiation and Isotopes | 2016 | 8 Pages |
Abstract
Present work evaluates the potential of a newly synthesized 68Ga-NOTA-folic acid conjugate for PET imaging of tumors over-expressing folate receptors (FRs). NOTA-folic acid conjugate was synthesized and characterized. It was radiolabeled with 68Ga in ⥠95% radiolabeling yields. In vitro cell binding studies showed a maximum cell uptake of 1.7±0.4% per million KB cells which was completely blocked on addition of cold folic acid showing specificity towards the FRs. However, further studies in tumor xenografts are warranted in order to assess the potential of 68Ga-folic acid complex for imaging tumors over-expressing FRs.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Akanksha Jain, Anupam Mathur, Usha Pandey, Jyotsna Bhatt, Archana Mukherjee, Ramu Ram, Haladhar Dev Sarma, Ashutosh Dash,