Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8209047 | Applied Radiation and Isotopes | 2016 | 5 Pages |
Abstract
A separation study using a 176Yb target for the preparation of nca 177Lu, which is a beta-emitting nuclide used not only in radioimmunotherapy applications but also in the treatment of various lesions, has been performed. A material having a better selectivity and separation efficiency for Lu than Yb was developed, and the separation conditions of 177Lu were derived using this from a neutron irradiated 176Yb target. The separation material was an organo-ceramic hybrid material containing a phosphate group. Adsorption behavior was determined through batch experiments, and 177Lu separation from the Yb target was evaluated through column experiments. The Yb target, with a 99.72% in 176Yb, was irradiated in the irradiation hole of HANARO, which has a thermal neutron flux of 1.6E+14 n cmâ2 sâ1. The batch experiments revealed that the organo-ceramic hybrid material (Sol-POS) had a separation factor of 1.6 at 0.5 M HCl. Separation was performed through extraction chromatography using a 5 mg enriched Yb target, and the separation yield of the NCA 177Lu was about 78%. If the amount of Yb target is increased to produce curies level 177Lu, additional purification will be needed.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Ul Jae Park, Jun-Sig Lee, Kang Hyuk Choi, Sung Soo Nam, Kook Hyun Yu,