| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8209048 | Applied Radiation and Isotopes | 2016 | 8 Pages |
Abstract
2-[18F]-Fluoro-3-pyridinecarboxaldehyde ([18F]FPCA) is a novel, water-soluble prosthetic group. It's radiochemistry has been developed and fully-automated for application in chemoselective radiolabelling of amino(oxy)-derivatised RI-OR2-TAT peptide, (Aoa-k)-RI-OR2-TAT, using a GE TRACERlab FX-FN. RI-OR2-TAT is a brain-penetrant, retro-inverso peptide that binds to amyloid species associated with Alzheimer's Disease. Radiolabelled (Aoa-k)-RI-OR2-TAT was reproducibly synthesised and the product of the reaction with FPCA has been fully characterised. In-vivo biodistribution of [18F]RI-OR2-TAT has been measured in Wistar rats.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
![Development & automation of a novel [18F]F prosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide](/preview/png/8209048.png "First Page Preview: Development & automation of a novel [18F]F prosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide")
Authors
Olivia Morris, J. Gregory, M. Kadirvel, Fiona Henderson, A. Blykers, Adam McMahon, Mark Taylor, David Allsop, Stuart Allan, J. Grigg, Herve Boutin, Christian Prenant,