Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8209138 | Applied Radiation and Isotopes | 2016 | 7 Pages |
Abstract
[11C]Raclopride is one of the most popular PET tracers used in Parkinson's disease studies. We previously prepared [11C]raclopride with reasonable yields using NaOH as an inorganic base, but the reaction patterns fluctuated. In this study, we describe the successful application of a commercially available 'super basic' proton sponge, TMGN, as a base for the [11C]methylation step using [11C]CH3OTf. This novel TMGN method produced better radiochemical yields, as well as enhanced reproducibility and a reduction in side products. Under optimal conditions (1.2 equiv. of TMGN), the radiochemical yield was 14.4±0.2% (ndc, EOS, n=5) and the specific activity was 66.6±13.3 GBq/mmol (n=5).
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Jihye Lee, Il-koo Cheong, Sang-Yoon Lee,