Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8209312 | Applied Radiation and Isotopes | 2016 | 6 Pages |
Abstract
Two 11C-labelled PET tracers, (R)-N-[11C]methyl-N-(3,3-dideuteropropargyl)-1-phenylpropan-2-amine ([11C]L-deprenyl-D2, [11C]DED) and (S)-N-[11C]methyl-N-propargyl-1-phenylpropan-2-amine ([11C]D-deprenyl, [11C]DDE) were synthesised. One step N-alkylation with [11C]MeI or [11C]MeOTf was performed using the automated platform TRACERlab® FX-C Pro. The labelled products were obtained with (37±15)% (n=10) (end of synthesis, decay corrected from [11C]MeI) radiochemical yields from [11C]MeI after 38±3 min synthesis time. In all cases, radiochemical purity was over 99% when [11C]MeOTf was used. This synthesis using a commercial platform makes these tracers more accessible for clinical research purposes.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Pablo Buccino, Ingrid Kreimerman, Kevin Zirbesegger, Williams Porcal, Eduardo Savio, Henry Engler,