Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8209617 | Applied Radiation and Isotopes | 2015 | 5 Pages |
Abstract
In this report we describe studies with N5-2OH, a carboranyl thymidine analog (CTA), which is a substrate for thymidine kinase 1 (TK1), using the F98 rat glioma model. In vivo BNCT studies have demonstrated that intracerebral (i.c.) osmotic pump infusion of N5-2OH yielded survival data equivalent to those obtained with i.v. administration of boronophenylalanine (BPA). The combination of N5-2OH and BPA resulted in a modest increase in MST of F98 glioma bearing rats compared to a statistically significant increase with the RG2 glioma model, as has been previously reported by us (Barth et al., 2008). This had lead us to synthesize a second generation of CTAs that have improved in vitro enzyme kinetics and in vivo tumor uptake (Agarwal et al., 2015).
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Rolf F. Barth, Weilian Yang, Robin J. Nakkula, Youngjoo Byun, Werner Tjarks, Lai Chu Wu, Peter J. Binns, Kent J. Riley,