Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8209665 | Applied Radiation and Isotopes | 2015 | 17 Pages |
Abstract
N-(2-[18F]fluoropropionyl)-l-glutamate([18F]FPGLU) was a recently developed potential amino acid tracer for tumor imaging with positron emission tomography-computer tomography (PET-CT). The absorbed and effective radiation doses resulting from the intravenous administration of [18F]FPGLU were estimated using biodistribution data from normal mice. The methodology recommended by Medical Internal Radiation Dose Committee (MIRD) was used to estimate the doses. The highest uptake of [18F]FPGLU was found in the kidneys, followed by the liver and lung. The kidneys were the organ received the highest absorbed dose, 58.4 μGy/MBq, the brain received the lowest dose, 5.5 μGy/MBq, and other organs received doses in the range of 8.3-11.9 μGy/MBq. The effective dose was 17.0 μSv/MBq. The data show that a 370 MBq (10 mCi) injection of [18F]FPGLU would lead to an estimated effective dose of 6.3 mSv, which is within the accepted range of routine nuclear medicine investigations.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Caihua Tang, Zeqing Xu, Kongzhen Hu, Baoguo Yao, Ganghua Tang, Dahong Nie,