Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8209806 | Applied Radiation and Isotopes | 2015 | 11 Pages |
Abstract
We evaluated and compared a new bombesin analog [Tyr-Gly5, Nle14]-BBN(6-14) conjugated to DOTA or DTPA and radiolabeled with In-111 in low and high GRPR expressing tumor models. Both peptides were radiolabeled with high radiochemical purity and specific activity. In vitro assays on T-47D, LNCaP and PC-3 cells showed that the affinity of peptides is similar and a higher binding and internalization of DOTA-peptide to PC-3 cells was observed. Both peptides could target PC-3 and LNCaP tumors in vivo and both tumor types could be visualized by microSPECT/CT.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Priscilla B. Pujatti, Julie M. Foster, Ciara Finucane, Chantelle D. Hudson, Jerome C. Burnet, Kerly F.M. Pasqualoto, Jair Mengatti, Stephen J. Mather, Elaine B. de Araújo, Jane K. Sosabowski,