Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8209863 | Applied Radiation and Isotopes | 2015 | 5 Pages |
Abstract
In this work a new coupling reagent, N-[2-(maleimido)ethyl]-3-(trimethylstannyl)benzamide, for radiohalogenation has been synthesized and characterized. The reagent is intended to either be attached to reduced disulfide bridges of proteins (making the halogenation site-specific) or to free terminal cysteine groups on peptides. The new reagent was also shown to be easily halogenated with inactive bromine and iodine as well as 125I and 211At, indicating potential use within targeted radiotherapy.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Emma Aneheim, Mark R. StJ. Foreman, Holger Jensen, Sture Lindegren,