Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8209865 | Applied Radiation and Isotopes | 2015 | 6 Pages |
Abstract
The aim of the present study was the evaluation and automation of the radiosynthesis of [11C]harmine for clinical trials. The following parameters have been investigated: amount of base, precursor concentration, solvent, reaction temperature and time. The optimum reaction conditions were determined to be 2-3 mg/mL precursor activated with 1 eq. 5 M NaOH in DMSO, 80 °C reaction temperature and 2 min reaction time. Under these conditions 6.1±1 GBq (51.0±11% based on [11C]CH3I, corrected for decay) of [11C]harmine (n=72) were obtained. The specific activity was 101.32±28.2 GBq/µmol (at EOS). All quality control parameters were in accordance with the standards for parenteral human application. Due to its reliability and high yields, this fully-automated synthesis method can be used as routine set-up.
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Authors
C. Philippe, M. Zeilinger, M. Mitterhauser, M. Dumanic, R. Lanzenberger, M. Hacker, W. Wadsak,