Comparative uptake of 18F-FEN-DPAZn2, 18F-FECH, 18F-fluoride, and 18F-FDG in fibrosarcoma and aseptic inflammation

The aim of this study is to evaluate uptake of 2-18F-fluoroethyl-bis(zinc(II)-dipicolylamine) (18F-FEN-DPAZn2) as a promising cell death imaging agent, a choline analog 18F-fluoroethylcholine (18F-FECH), 18F-fluoride as a bone imaging agent, and a glucose analog 2−18F-fluoro-2-deoxy-d-glucose (18F-FDG) in the combined S180 fibrosarcoma and turpentine-induced inflammation mice models. The results showed that 18F-FDG had the highest tumor-to-blood uptake ratio and tumor-to-muscle ratio, and high inflammation-to-blood ratio and inflammation-to-muscle ratio. 18F -FECH showed moderate tumor-to-blood ratio and tumor-to-muscle ratio, and low inflammation-to-blood ratio and inflammation-to-muscle ratio. However, accumulation of 18F FEN-DPAZn2 in tumor was similar to that in normal muscle. Also, 18F-FEN-DPAZn2 and 18F-fluoride exhibited the best selectivity to inflammation. 18F-FECH positron emission tomography (PET) imaging demonstrates some advantages over 18F-FDG PET for the differentiation of tumor from inflammation. 18F FEN-DPAZn2 and 18F-fluoride can be used for PET imaging of aseptic inflammation.