| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8210221 | Applied Radiation and Isotopes | 2014 | 7 Pages |
Abstract
Preparation of three mucoadhesive formulations was optimized and pharmaceutically evaluated. Ofloxacin was radiolabeled with 99mTc and radiolabeled complex was characterized by HPLC. 99mTc-Ofloxacin was added as a tracer to the formulations namely Oflox C934, Oflox C940 and Oflox HPMC and the formulations were fed orally to rats. Imaging studies were carried out to assess the prolonged gastric retention of the formulations. 99mTc-Ofloxacin served as a good tracer for studying the pharmacokinetics of three controlled release mucoadhesive dosage forms by gamma scintigraphy studies.
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Authors
Archana Mukherjee, Subhashree Sahoo, Haladhar Dev Sarma, Chandra Kanti Chakraborti, Grace Samuel,