| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8211021 | International Journal of Radiation Oncology*Biology*Physics | 2018 | 14 Pages |
Abstract
High-dose single-fraction SBRT induced tumor necrosis, desmoplasia, and tumor apoptosis and decreased tumor vessel density within 24Â hours, even in renal cell metastases. The role of immune cells seems limited in this early phase. These first-in-human results imply direct vascular and DNA damage mechanisms important in the clinical efficacy specific to spinal SBRT.
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Authors
Jasper G. BSc, Stefan M. MD, PhD, Marielle E.P. PhD, Nicolien MD, Wietse S.C. MD, Anne L. MD, Joanne M. MD, Salman BSc, MD, FRCPC, Arjun BSc, MD, FRCPC, Jorrit-Jan MD, PhD,