| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8211362 | International Journal of Radiation Oncology*Biology*Physics | 2018 | 23 Pages |
Abstract
Although PARP inhibition enhanced the antitumor response to fractionated irradiation, it also enhanced the irradiation response in replicating normal tissues. Therefore, our study suggests that additional caution may be warranted in the clinical development of combination therapies using PARP inhibitors and radiation therapy, in particular where the field of irradiation includes the esophagus.
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Authors
Luiza Madia Lourenco, Yanyan PhD, Neele MSc, Marcus Green, Fiona MSc, Agata PhD, Yasmin Shanneik, John PhD, Anderson J. PhD,