| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8213625 | International Journal of Radiation Oncology*Biology*Physics | 2016 | 32 Pages |
Abstract
The mitochondrial dysfunction observed in CRR cells contributes to X-ray and DTX cross-resistance. The activation of oxidative phosphorylation in CRR cells may represent an effective approach to overcome radioresistant cancers. In general, the overexpression of β-tubulin or multidrug efflux pumps is thought to be involved in DTX resistance. In the present study, we discovered another DTX resistant mechanism by investigating CRR cells.
Related Topics
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Authors
Yoshikazu PhD, Mehryar Habibi PhD, Masatoshi PhD, Yusuke PhD, Motoi MD, PhD, Yohei PhD, Manabu MD, PhD,