| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8222106 | International Journal of Radiation Oncology*Biology*Physics | 2013 | 7 Pages |
Abstract
We present a novel strategy for optimizing proton therapy to maximize dose-averaged LET in tumor targets while simultaneously minimizing dose-averaged LET in normal tissue structures. MCO BPs show substantial LET variations, leading to potentially significant differences in RBE-weighted doses. Pareto-surface navigation, using both dose and LET distributions for guidance, provides the means for evaluating a large variety of deliverable plans and aids in identifying the clinically optimal solution.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Drosoula PhD, Clemens MS, David PhD, Andrzej PhD, Alexei PhD, Harald PhD,