| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8222771 | International Journal of Radiation Oncology*Biology*Physics | 2013 | 8 Pages |
Abstract
High LET radiation significantly reduces NBS1/BRCA1-mediated monoubiquitination of γ-tubulin and amplifies centrosome overduplication with a peak at 100 keV/μm. In contrast, Ku70 and DNA-PKcs deficiencies mitigate centrosome overduplication, although deficiencies of both NBS1/BRCA1 and Ku70/DNA-PKcs markedly enhance cell killing.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Mikio PhD, Ryoichi PhD, Kenshi PhD,