Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8225380 | International Journal of Radiation Oncology*Biology*Physics | 2012 | 7 Pages |
Abstract
The model presented in this work accurately reproduces cell survival following modulated radiation exposures, both in and out of the primary treatment field, by incorporating a bystander component. In addition, the model suggests that the bystander effect is responsible for a significant portion of cell killing in uniformly irradiated cells, 50% and 70% at doses of 2 Gy in AGO1522 and DU145 cells, respectively. This description is a significant departure from accepted radiobiological models and may have a significant impact on optimization of treatment planning approaches if proven to be applicable in vivo.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Stephen J. Ph.D., Karl T. Ph.D., Conor K. M.Sc., Colman B.Sc., Joe M. FRR(RCSI), Alan R. Ph.D., Kevin M. Ph.D.,