Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8226445 | International Journal of Radiation Oncology*Biology*Physics | 2012 | 10 Pages |
Abstract
Stem-like gliomaspheres are resistant to irradiation-induced cytotoxicity, G2/M arrest, and DNA DSBs, compared with nonstem glioma cells. Gefitinib differentially enhances radiosensitivity of stem-like gliomaspheres by reducing EGFR-Akt activation and DNA-PKcs expression, accompanied by enhanced irradiation-induced DNA DSBs and inhibition of DSB repair.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Khong Bee Ph.D., Congju Ph.D., Yin Ling B.S., Qiuhan B.S., Albert M.D., Meng Cheong F.R.C.P.,