Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8226911 | International Journal of Radiation Oncology*Biology*Physics | 2012 | 9 Pages |
Abstract
Radiation-induced enhancement of adenoviral transgene expression is linked to DNA damage recognition and repair. Radiation induces a global cellular response that results in increased production of RNA and proteins, including adenoviral transgene products. This study provides a mechanistic rationale for combining radiation with adenoviral gene delivery.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Petri M.D., M.Sc., Maria M.D., Ph.D., Sari Ph.D., Sophie D.V.M., Ph.D., Rabah M.Sc., Mikko Ph.D., Laura Ph.D., Akseli M.D., Ph.D.,