Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8229469 | International Journal of Radiation Oncology*Biology*Physics | 2011 | 7 Pages |
Abstract
To our knowledge, this is the first report to find an association between MSH2 and MSH3 genetic variants and the development of radiosensitivity in breast cancer patients. Our findings suggest the hypothesis that mismatch repair mechanisms may be involved in cellular response to radiotherapy. Genetic polymorphisms may be promising candidates for predicting acute radiosensitivity, but further studies are necessary to confirm our findings.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Monica M.D., Ph.D., Simonetta M.Sc., Francesca Ph.D., Cristina M.Sc., Giampaolo M.D., Lorenzo M.D., Emanuela M.D., Ph.D., Adele Seniori M.D., Giuseppe M.D.,