Evaluation of Single Nucleotide Polymorphisms (SNPs) in the p53 Binding Protein 1 (TP53BP1) Gene in Breast Cancer Patients Treated With Breast-Conserving Surgery and Whole-Breast Irradiation (BCS + RT)

Article ID	Journal	Published Year	Pages	File Type
8229970	International Journal of Radiation OncologyBiologyPhysics	2011	7 Pages	PDF

Abstract

This novel avenue of investigation of polymorphisms in radiation repair/response genes in patients treated with BCS + RT suggests a correlation to local relapse. Additional evaluation is needed to assess the biological and functional significance of these single nucleotide polymorphisms, and larger confirmatory validation studies will be required to determine the clinical implications.

Keywords

Breast-conserving surgery Breast cancer Single nucleotide polymorphism

Related Topics

Physical Sciences and Engineering Physics and Astronomy Radiation

Preview

Evaluation of Single Nucleotide Polymorphisms (SNPs) in the p53 Binding Protein 1 (TP53BP1) Gene in Breast Cancer Patients Treated With Breast-Conserving Surgery and Whole-Breast Irradiation (BCS + RT)

Authors

Bruce G. M.D., Sharad M.D., Diptee Ph.D., Camille M.D., Alexi Ph.D., Devora B.S., Meena S. M.D., Qifeng M.D., Ph.D., Shridar M.D., Kim M. M.D., Ph.D.,