| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8230017 | International Journal of Radiation Oncology*Biology*Physics | 2011 | 8 Pages |
Abstract
Our studies show that in RIT, damaged megakaryocytes release PF4 locally, inhibiting platelet recovery. Blocking PF4 enhances recovery while released PF4 from megakaryocytes limits TPO efficacy, potentially because of increased release of PF4 stimulated by TPO. The clinical value of blocking this negative paracrine pathway post-RIT remains to be determined.
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Authors
Michele P. M.D., Liqing Ph.D., Yvonne Nguyen, M. Anna Ph.D., Mortimer M.D.,