Targeting the AKT/GSK3Î²/Cyclin D1/Cdk4 Survival Signaling Pathway for Eradication of Tumor Radioresistance Acquired by Fractionated Radiotherapy

Article ID	Journal	Published Year	Pages	File Type
8230211	International Journal of Radiation OncologyBiologyPhysics	2011	9 Pages	PDF

Abstract

Cyclin D1/Cdk4 is a critical target of the AKT survival signaling pathway responsible for tumor radioresistance. Targeting the AKT/GSK3Î²/cyclin D1/Cdk4 pathway would provide a novel approach to improve fractionated RT and would have an impact on tumor eradication in combination with chemotherapy.

Keywords

Cyclin D1 Akt Fractionated radiation Radioresistance Akt inhibitor

Related Topics

Physical Sciences and Engineering Physics and Astronomy Radiation

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Targeting the AKT/GSK3Î²/Cyclin D1/Cdk4 Survival Signaling Pathway for Eradication of Tumor Radioresistance Acquired by Fractionated Radiotherapy

Authors

Tsutomu Ph.D., Satoshi M. Med., Yasushi B.Sc., Yoshikazu Ph.D., Yoshihiro M.D., Ph.D., Manabu M.D., Ph.D.,