DNA Repair Alterations in Children With Pediatric Malignancies: Novel Opportunities to Identify Patients at Risk for High-Grade Toxicities

Article ID	Journal	Published Year	Pages	File Type
8231745	International Journal of Radiation OncologyBiologyPhysics	2010	11 Pages	PDF

Abstract

Double-strand break repair alteration in children may predispose to cancer formation and may affect children's susceptibility to normal-tissue toxicities. Phosphorylated H2AX analysis of blood samples allows one to detect DSB repair deficiencies and thus enables identification of children at risk for high-grade toxicities.

Keywords

DNA double-strand breaks DNA repair Predictive assay Childhood cancer Normal tissue toxicity

Related Topics

Physical Sciences and Engineering Physics and Astronomy Radiation

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DNA Repair Alterations in Children With Pediatric Malignancies: Novel Opportunities to Identify Patients at Risk for High-Grade Toxicities

Authors

Claudia E. M.D., Ph.D., Andreas Ph.D., Ruth M.D., Karin M.D., Martin Ph.D., Jochen M.D., Stefan Ph.D., Norbert M.D., Ph.D., Christian M.D., Ph.D.,