| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8232369 | International Journal of Radiation Oncology*Biology*Physics | 2010 | 9 Pages |
Abstract
We provide evidence that IR activates AMPK in human cancer cells in an LKB1-independent manner, leading to induction of p21waf/cip and regulation of the cell cycle and survival. AMPK appears to (1) participate in an ATM-AMPK-p21waf/cip pathway, (2) be involved in regulation of the IR-induced G2/M checkpoint, and (3) may be targeted by metformin to enhance IR responses.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Toran M.Sc., Ayesha B.Sc., Caiqiong M.Sc., Shane B.Sc., Robert G. M.D., Ph.D., Jean-Claude M.D., Gurmit Ph.D., James M.D., Theodoros M.D., Ph.D.,