Andrographolide Sensitizes Ras-Transformed Cells to Radiation in vitro and in vivo

Andrographolide sensitized Ras-transformed cells to radiation both in vitro and in vivo. Andrographolide-mediated radiosensitization was associated with downregulation of Akt and NF-κB activity. These observations indicate that andrographolide is a novel radiosensitizing agent with potential application in cancer radiotherapy.