Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8233430 | International Journal of Radiation Oncology*Biology*Physics | 2010 | 8 Pages |
Abstract
A review of literature on the development of sensorineural hearing loss after high-dose radiation therapy for head-and-neck tumors and stereotactic radiosurgery or fractionated stereotactic radiotherapy for the treatment of vestibular schwannoma is presented. Because of the small volume of the cochlea a dose-volume analysis is not feasible. Instead, the current literature on the effect of the mean dose received by the cochlea and other treatment- and patient-related factors on outcome are evaluated. Based on the data, a specific threshold dose to cochlea for sensorineural hearing loss cannot be determined; therefore, dose-prescription limits are suggested. A standard for evaluating radiation therapy-associated ototoxicity as well as a detailed approach for scoring toxicity is presented.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Niranjan M.S., Andrew Ph.D., Avraham M.D., Charlie C. M.D., John C. M.D., Patrick M.D., William M. M.D.,