Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8233555 | International Journal of Radiation Oncology*Biology*Physics | 2010 | 7 Pages |
Abstract
Published data suggest that the risk of moderately severe (â¥Grade 3) radiation-induced acute small-bowel toxicity can be predicted with a threshold model whereby for a given dose level, D, if the volume receiving that dose or greater (VD) exceeds a threshold quantity, the risk of toxicity escalates. Estimates of VD depend on the means of structure segmenting (e.g., V15 = 120 cc if individual bowel loops are outlined or V45 = 195 cc if entire peritoneal potential space of bowel is outlined). A similar predictive model of acute toxicity is not available for stomach. Late small-bowel/stomach toxicity is likely related to maximum dose and/or volume threshold parameters qualitatively similar to those related to acute toxicity risk. Concurrent chemotherapy has been associated with a higher risk of acute toxicity, and a history of abdominal surgery has been associated with a higher risk of late toxicity.
Related Topics
Physical Sciences and Engineering
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Radiation
Authors
Brian D. M.D., M.P.H., Charlie C. MD., Laura A. M.D., Shiva K. Ph.D., X. Allen Ph.D., Randall K. Ph.D., Moyed Ph.D.,