Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8233655 | International Journal of Radiation Oncology*Biology*Physics | 2010 | 6 Pages |
Abstract
Biomarkers are of interest for predicting or monitoring normal tissue toxicity of radiation therapy. Advances in molecular radiobiology provide novel leads in the search for normal tissue biomarkers with sufficient sensitivity and specificity to become clinically useful. This article reviews examples of studies of biomarkers as predictive markers, as response markers, or as surrogate endpoints for radiation side effects. Single nucleotide polymorphisms are briefly discussed in the context of candidate gene and genomewide association studies. The importance of adjusting for radiation dose distribution in normal tissue biomarker studies is underlined. Finally, research priorities in this field are identified and discussed.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Søren M. Ph.D., D.Sc., Matthew M.D., Joseph O. Ph.D., Adam M.D., Ph.D., Walter J. M.D., Jacqueline P. Ph.D., Barry S. Ph.D.,