Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8233694 | International Journal of Radiation Oncology*Biology*Physics | 2010 | 8 Pages |
Abstract
Radiation-induced DSBs accumulate similarly in acute- and late-responding tissues during fractionated irradiation, whereas the whole extent of residual DNA damage depends decisively on the underlying genetically defined DSB repair capacity. Moreover, our data indicate that even minor impairments in DSB repair lead to exceeding DNA damage accumulation during fractionated irradiation and thus may have a significant impact on normal tissue responses in clinical radiotherapy.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Claudia E. M.D., Ph.D., Andreas Ph.D., Juliane Wendorf, Annika Stützel, Martin Ph.D., Mei Fang Ph.D., Peter Ph.D., Christian M.D., Ph.D.,