Article ID Journal Published Year Pages File Type
8233694 International Journal of Radiation Oncology*Biology*Physics 2010 8 Pages PDF
Abstract
Radiation-induced DSBs accumulate similarly in acute- and late-responding tissues during fractionated irradiation, whereas the whole extent of residual DNA damage depends decisively on the underlying genetically defined DSB repair capacity. Moreover, our data indicate that even minor impairments in DSB repair lead to exceeding DNA damage accumulation during fractionated irradiation and thus may have a significant impact on normal tissue responses in clinical radiotherapy.
Related Topics
Physical Sciences and Engineering Physics and Astronomy Radiation
Authors
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