Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8233955 | International Journal of Radiation Oncology*Biology*Physics | 2010 | 8 Pages |
Abstract
SAHA shows efficacy as a radiosensitizer at clinically obtainable levels. In its presence, targeted DNA strand breaks occur over an expanded region, indicating increased chromatin access. The rejoining of such breaks is degraded by SAHA when measured as rearrangements at the molecular level and rejoining that contributes to cell survival.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Sheetal Ph.D., Hongan B.S., Shyh-Jen Ph.D., Bay B.S., Andrew T. Ph.D.,