Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8234078 | International Journal of Radiation Oncology*Biology*Physics | 2009 | 7 Pages |
Abstract
After GliaSite treatment, characteristic T1- and T2-weighted changes are seen on MRI. Greater T1-weighted changes in the absence of increasing edema appears not to indicate disease progression; however, greater T2-weighted changes were associated with decreased survival. These findings suggest that T1-weighted enhancement in the absence of concomitant edema after GliaSite treatment might represent pseudoprogression. Conversely, increasing T2-weighted hyperintensity might reflect infiltrative disease progression. These results provide a framework for the analysis of disease control in future prospective studies of GliaSite treatment.
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Authors
Lawrence M.D., Geoffrey M.D., John D. M.D., Michele R.N., Alessandro M.D., Nicholas A. Ph.D., Timothy A. M.D., Ph.D.,