Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8235695 | International Journal of Radiation Oncology*Biology*Physics | 2009 | 7 Pages |
Abstract
A genetic deficiency of PAI-1 is associated with amelioration of late radiation enteropathy. Pharmacological inhibition of PAI-1 by PAI-039 positively impacts the early, acute phase increase in plasma PAI-1 and the associated radiation-induced gene expression of inflammatory/extracellular matrix proteins. Since PAI-039 has been shown to inhibit the active form of PAI-1, as opposed to the complete loss of PAI-1 in the knockout animals, these data suggest that a PAI-1 inhibitor could be beneficial in treating radiation-induced tissue injury in acute settings where PAI-1 is elevated.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Rym M.S., Agnès Ph.D., Valérie B.S., Marc Ph.D., Jean-Christophe M.D., Ph.D., David L. Ph.D., Fabien Ph.D.,