Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8236083 | International Journal of Radiation Oncology*Biology*Physics | 2009 | 7 Pages |
Abstract
SAHA was an effective radiosensitizer in experimental colorectal carcinoma models, suggesting that histone deacetylase inhibition might constitute a valuable supplement to current multimodal treatment strategies in rectal cancer. The presence of histone hyperacetylation at radiation was not required to obtain an increased radiation response, questioning the validity of using histone hyperacetylation as a molecular marker for radiosensitivity.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Sigurd M.D., Anne Hansen M.D., Ph.D., Torbjørn M.Sc., Thomas B.Sc., Kjersti M.D., Ph.D.,