Article ID Journal Published Year Pages File Type
8236083 International Journal of Radiation Oncology*Biology*Physics 2009 7 Pages PDF
Abstract
SAHA was an effective radiosensitizer in experimental colorectal carcinoma models, suggesting that histone deacetylase inhibition might constitute a valuable supplement to current multimodal treatment strategies in rectal cancer. The presence of histone hyperacetylation at radiation was not required to obtain an increased radiation response, questioning the validity of using histone hyperacetylation as a molecular marker for radiosensitivity.
Related Topics
Physical Sciences and Engineering Physics and Astronomy Radiation
Authors
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