Article ID Journal Published Year Pages File Type
8236538 International Journal of Radiation Oncology*Biology*Physics 2009 10 Pages PDF
Abstract
Use of RT alone with doses of less than 40 Gy did not result in clinically significant hearing loss. High-frequency SNHL was profoundly damaged in patients who received concomitant cisplatin when doses of 100 mg/m2 were used. The threshold cochlear dose for hearing loss with cisplatin-based chemotherapy and RT was predicted to be 10 Gy. The inner ear radiation dose constraints and cisplatin dose intensity should be considered in the treatment of advanced head-and-neck cancer.
Related Topics
Physical Sciences and Engineering Physics and Astronomy Radiation
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