| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8236590 | International Journal of Radiation Oncology*Biology*Physics | 2009 | 8 Pages |
Abstract
We demonstrated that highly conformal radiation can be reproducibly delivered to a small volume of rodent lung on a widely available clinical unit. The radiation-induced lung injury can be detected as early as 2 months after radiation with perfusion MRI. The primary pattern of injury agrees with previously reported endothelial damage to radiosurgical radiation doses. This experimental design provides a cost-effective methodology for producing radiosurgical injuries in rodents that reproduces current human treatments for studying radiation injury and agents that might affect it.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Jing Ph.D., Jaime F. Ph.D., Matthew D. M.D., Klaus D. M.D., John P. Ph.D., James M. M.D., Ke Ph.D., Paul W. M.D., Ph.D,