| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8237049 | International Journal of Radiation Oncology*Biology*Physics | 2009 | 8 Pages |
Abstract
This is the first study reporting the overexpression of STAT1 in human clear cell and papillary RCC tissues. Radiosensitization in RCC cell lines was observed by a reduction or inhibition of STAT1 signaling, using fludarabine or siRNA. Our data suggest that STAT1 may play a key role in RCC radioresistance and manipulation of this pathway may enhance the efficacy of radiotherapy.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Zhouguang M.D., Ph.D., Maria M.D., Ph.D., Zhongfa Ph.D., Yan Ph.D., Xiaozhen M.D., Ph.D., Julie Xiaohong M.D., Yuanhong M.D., Ph.D., Weiyuan M.D., Kyle Ph.D., Chao-Nan M.D., Ph.D., Robert D.O., E. Brian M.D., Bin Tean M.D., Ph.D., Bin S. M.D.,