| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8237237 | International Journal of Radiation Oncology*Biology*Physics | 2008 | 10 Pages |
Abstract
The results of our study have shown that KU-0059436 increases radiosensitivity in a replication-dependent manner that is enhanced by fractionation. A mechanism is proposed whereby PARP inhibition increases the incidence of collapsed replication forks after ionizing radiation, generating persistent DNA double-strand breaks. These observations indicate that KU-0059436 is likely to enhance the therapeutic ratio achieved by radiotherapy in the treatment of glioblastoma multiforme. A Phase I clinical trial is in development.
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Authors
Fiona A. B.Sc., Dana A. M.Sc., Anthony J. F.R.C.R., Ph.D.,