| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8237609 | International Journal of Radiation Oncology*Biology*Physics | 2008 | 10 Pages |
Abstract
Irradiation-induced apoptosis is strongly enhanced by targeting the pro-apoptotic TRAIL receptors DR4 or DR5. Irradiation results in a p53-dependent increase in DR5 membrane expression. The sensitizing effect of rhTRAIL on irradiation in the HeLa cell line is, however especially mediated through the DR4 receptor.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
John H. M.D., Elisabeth G.E. M.D., Ph.D., Gert-Jan Meersma, Brigitte M.T. Ph.D., Ate G.J. M.D., Ph.D., Steven Ph.D.,