Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8237929 | International Journal of Radiation Oncology*Biology*Physics | 2008 | 8 Pages |
Abstract
These findings are consistent with the suggestion that a promiscuous, deletion-prone abnormality of nonhomologous end joining might underpin the predisposition of certain radiotherapy patients to late radionecrosis. We hypothesize that some individuals might harbor subclinical defects in nonhomologous end joining that clinically manifest on challenge with high-dose radiation. Because both quantitative and qualitative aspects of end joining have demonstrably been influenced, we recommend that the study of patient samples should involve a combination of quantitative methods (e.g., quantitative real-time polymerase chain reaction), sequencing analysis, and a comparison of multiple join types.
Related Topics
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Authors
Wu-Meng M.B.B.Chir., Ph.D., Malcolm C. Ph.D., Ghee Chong Ph.D., Hui Hua Ph.D., Allan Ph.D., F.R.C.R., F.R.C.P., Susan L.E. M.D., F.R.C.R., F.R.C.P.,