| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8238060 | International Journal of Radiation Oncology*Biology*Physics | 2008 | 8 Pages |
Abstract
In breast cancer patients treated with CS+RT, COX-2 expression is associated with younger age, larger tumor size, worse local control, distant metastasis, and worse overall survival. The significance is limited to hormone receptor-positive tumors, consistent with the known effect of COX-2/PGE2 on aromatase activity. Use of COX-2 inhibitors in estrogen-dependent breast cancers warrants further investigation.
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Authors
Bruce G. M.D., Qifeng M.D., Ph.D., Meena S. M.D., Antoinette R. M.D., Michael M.D.,