18F-Fluorodeoxyglucose Positron Emission Tomography-Based Assessment of Local Failure Patterns in Non-Small-Cell Lung Cancer Treated With Definitive Radiotherapy

At lower doses, the pattern of recurrences was mostly within the GTV, suggesting that the dose might have been a factor for tumor control. At greater doses, the treatment failures were mostly at the margin of the GTV. This suggests that visual incorporation of PET data for GTV delineation might be inadequate, and more sophisticated approaches of PET registration should be evaluated.