Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8240209 | International Journal of Radiation Oncology*Biology*Physics | 2008 | 12 Pages |
Abstract
The data indicate that Bax and Bak have nonredundant functional roles in the apoptotic response of the irradiated intestinal endothelium. The observation that Bax deficiency and Bak deficiency also protect crypts in the microcolony assay provides strong evidence that the microvascular apoptotic component is germane to the mechanism of radiation-induced damage to mouse intestines, regulating reproductive cell death of crypt stem cell clonogens.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Jimmy A. Ph.D., Jerzy G. M.D., Regina Feldman, Decheng Ph.D., Adriana Ph.D., Carlos M.D., Emily H.-Y. M.D., Ph.D., Richard M.D., Zvi M.D.,